The increasing digitalization of the economy leads to shorter innovation cycles and faster market penetration of products. In this fast-moving environment, a gradual adaptation of technologies and business models is causing companies to fall behind. It is therefore essential for companies to master the organizational ability to both increase efficiency in their core business and to innovate exploratively using new technologies. Only this ensures long-term success. This ability is called ambidexterity and the white paper presents proven practices how this can be used in companies.